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doi: 10.1001/jamadermatol.2014.1875

You'll need 20-30% higher doses to achieve the same subjective effects you experienced during your previous cycle because GHRH receptors haven't fully upregulated

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Lets take a look at a few animal studies as examples: Adding stress hormones causes mitochondrial dysfunction: The addition of corticosterone in mice will cause depression, and this is one way of making a mouse model of depression