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21 , e00101 (2019)

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Occupancy stays low, but each engaged receptor keeps sending its main message longer than it would under a balanced signal (cAMP bias with low receptor internalization). In a head-to-head trial against liraglutide, tirzepatide reduced measured food intake and craving more despite lower GLP-1 occupancy. The effect lowers the drive to eat rather than increasing restraint

Peptides are a complex subject with strange drug names, shared and sometimes contradictory potential effects, and confusing regulatory statuses

J., Mezquita-Raya, P., Carretero-Gmez, J., et al