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The second line of antioxidant defense involves the synthesis of a thioredoxin redox system in which reduced thioredoxin (TRX) catalyzes the reduction of disulfides (SS) and is itself oxidized and subsequently reduced by thioredoxin reductase at the expense of NADPH

Another study using ellagic acid to treat oxygen-glucose deprivation and reoxygenation models of rat cortical neurons cultured in vitro found a significantly reduced volume of cerebral infarction and improved neurological deficit score in rats by increasing the Bcl-2/Bax ratio (Rehman et al., 2019)

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Moreover, HPs60 therapy was demonstrated to influence the expression of microRNAs (miRNAs) in cancer-bearing animals (488)

doi: 10.1016/j.encep.2016.06.007