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In rodents, methionine restriction can increase lifespan by about 45%, decrease age-related diseases ( e.g

Several methods are available to diagnose mHE, including common tests such as Psychometric Hepatic Encephalopathy Score (PHES), Critical Flicker Frequency (CFF) and Electroencephalogram (EEG)

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In a depressive-like monkey model, significant changes in the gut microbiota were observed, and lipidomic analysis revealed abnormal lipid metabolism in brain regions (171)

Expression of this mutated gene greatly reduces expression and operation of astrocytic glutamate transporters, thus leading to an excitotoxicity linked to psychosocial abnormalities and impaired cognition