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At the molecular level, trivalent chromium enhances the kinase activity of the insulin receptor, facilitating the crucial phosphorylation steps that allow the receptor to transmit its signal into the cell

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It has been shown that atg5 (an autosomal marker) null mice crossed with Lurcher mice have an increase of PCs death, more than Lurcher mice with atg5, which eventually suggests that atg5 rather protects the PCs in Lurcher mice than causes cell death by autophagy [98]