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Balogh M, Varga BK, Karadi DA, Riba P, Puskar Z, Kozsurek M, Al-Khrasani M, Kiraly K (2019) Similarity and dissimilarity in antinociceptive effects of dipeptidyl-peptidase 4 inhibitors, Diprotin A and vildagliptin in rat inflammatory pain models following spinal administration
A 2024 study of the same population utilizing Tirzepatide found similar results, with participants experiencing improved health and reduced risk of fatal cardiovascular events
Future studies should clarify these context-specific mechanisms to enable safe and precise application of SIRT1-targeted therapies in metabolic liver disease
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