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Semaglutide is administered as a once-weekly subcutaneous injection (marketed as Ozempic for diabetes and Wegovy for weight management) or as a daily oral tablet (Rybelsus)

However, given that previous demonstrations of longevity resulting from disruption of this pathway occurred either at conception or in young adulthood 6,7,17,18,19 , along with the reported importance of low exposure to GH (and IGF-1) signals early in life on longevity and related outcomes 20,21 , whether benefits can be achieved by targeting this pathway later in life is unclear

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