Side effects include nausea and gastrointestinal issues, and many patients report reduced cravings, but also a loss of appetite or inability to enjoy certain foods
The putative role of neuroinflammation in the complex pathophysiology of migraine: from bench to bedside
However, healthy individuals synthesise glutathione endogenously at rates sufficient to meet this demand if dietary intake of cysteine, glutamate, and glycine is adequate
However, this low rate of serious events creates a false sense that all discomfort should be dismissed as "the drug working." Persistent constipation, worsening stomach pain, or escalating symptoms often get normalized as inevitable rather than reported, blurring the line between expected adjustment and situations requiring medical attention
References PubMed: Physiology of GLP-1 DrugBank: GLP-1 biological role NCBI Bookshelf: Incretin hormones overview StatPearls: GLP-1 physiology [Textbook: Goodman & Gilmans The Pharmacological Basis of Therapeutics, 13th ed.]