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However, while this dual mechanism of drug delivery and ROS-generation enhances antitumour efficacy, the potential for off-target oxidative damage to healthy brain cells and associated neurotoxicity was not comprehensively evaluated, which may in-turn limit translational interpretation

Sterile water has no preservative, so once the seal is punctured, it can easily become contaminated with bacteria

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Why this trial matters: First bispecific + CD38 combo to show superior PFS and OS in Phase III in RRMM Potential new standard of care as early as second-line Demonstrates deep responses, high MRD-negativity, and durable outcomes First-line Strategies in BRAF V600E-Mutant mCRC: Real-World Evidence Signals Treatment Priorities In a real-world retrospective cohort of patients with BRAF V600E-mutant metastatic colorectal cancer (mCRC), frontline chemotherapy plus anti-VEGF therapy was associated with the longest survival outcomes, while BRAF-targeted strategies showed promising response rates, emphasizing the need for tailored therapy and prospective validation

Factors Associated with Symptom Response to Pyloric Injection of Botulinum Toxin in a Large Series of Gastroparesis Patients