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10.1371/journal.pone.0042165

The simple answer is that nobody knows

Introduction For millions of people, the morning brew represents more than just a caffeine boostits a cherished ritual that kickstarts the day

the useful additions in a research protocol are ones that address a step the current blend does not touch

Venkateshappa C, Harish G, Mahadevan A, Bharath MS, Shankar SK (2012) Elevated oxidative stress and decreased antioxidant function in the human hippocampus and frontal cortex with increasing age: implications for neurodegeneration in Alzheimers disease