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The mechanism by which GLP-1 agonists reduce alcohol intake in humans is currently unknown, though a recent RCT reported reduced alcohol cue reactivity in the nucleus accumbens (NAc), a key region associated with alcohols rewarding properties, after treatment with the GLP-1 agonist Exenatide 11

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Leggio and his colleagues noted that, compared with other GLP-1 receptor agonists, semaglutide is more potent, has a higher affinity for its receptor, and is longer acting

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