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In an experimental study performed in 5/6 nephrectomized normo- and hyperuricemic rats, febuxostat protected against renal damage, and prevented proteinuria, preserving vessel morphology and glomerular pressure, thus it prevents progression of CKD independently of its effect on UA.46 In the FOCUS47 extension study, 116 patients treated with febuxostat were followed for 5 years

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However, in p53 wild-type glioblastoma, p62 attenuates ferroptosis and promotes SLC7A11 expression

This arrangement not only prevents glutamate (Glu) leakage of Glu, but also facilitates the exchange function of ions, neurotransmitters, and other small molecules ( Recently, numerous studies have reported that NPP formation appears to be associated with synaptic plasticity changes mediated by central glial cells