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When immune cells adopt a proinflammatory metabolic phenotype, for example M1-dominant macrophages, elevated ROS production and disrupted iron homeostasis often predispose both these cells and surrounding tissues to ferroptosis

Cloonan et al., 2017)

But they come with significant drawbacks: high cost, injection site reactions, increased infection risk due to immune suppression, and the development of anti-drug antibodies over time that can reduce efficacy

My skin feels more hydrated and has a noticeable glow