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The authors of this study also observed that a moderate intake of folic acid in the ART population is associated with reduced DNA methylation variance in imprinting control regions [KCNQ1 overlapping transcript 1 (Kcnq1ot1), small nuclear ribonucleoprotein polypeptide N (SNRPN) and paternally expressed gene 1 (PEG1)] and increased global DNA methylation levels in both embryonic and placental tissues (84)