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Petersburg, Russia Initial research in 1980s at Institute of Bioregulation and Gerontology Derived from studying pineal gland peptides and aging Over 40 years of Russian research (but limited Western studies) Inspired by observation that pineal gland function declines with age Why developed: Soviet/Russian focus on longevity research Searching for ways to extend healthy lifespan Understanding cellular aging mechanisms Pineal gland's role in aging and circadian rhythms Goal: Create synthetic peptide mimicking natural bioregulators Epithalon vs epithalamin: Epithalamin: Natural polypeptide complex from pineal glands (bovine) Epithalon: Synthetic tetrapeptide mimicking epithalamin's active component Epithalon more practical (synthetic production, consistent quality) Both target similar anti-aging pathways Learn peptide fundamentals and how peptides work at SeekPeptides to understand Epithalon's unique mechanisms

Mann DM, Yates PO

The median and upper 2.5 th percentile of the adult population by age and sex are presented in Table 20b.3 Measurement of erythrocyte glutathionine reductase activity Only small samples of blood are required for the EGR assay, and fasting samples are not necessary (Komindr and Nichoalds, 1980)

Sikiric and colleagues have proposed nitric oxide system involvement, while other groups have documented effects on VEGF receptor 2 expression, growth-hormone receptor upregulation, and dopamine pathway modulation