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If gallbladder disease is diagnosed, management depends on severity and may range from conservative observation for asymptomatic gallstones to cholecystectomy (surgical gallbladder removal) for acute cholecystitis or symptomatic cholelithiasis

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2012 May 1;3(3):3629

Permutation tests validated the model, with P -values of prediction accuracy during training ( P = 0.05) and separation distance ( P = 0.04) within the significance threshold ( Supplementary Figure S2 )