Absorption from intramuscular and subcutaneous sites changes as muscle mass and blood flow change
In affective disorders such as depression, BD, and PTSD, alterations in serotonergic, dopaminergic, and GABAergic signaling often regulated by microbial misbalanced signaling render gut microbiome as strongly connected to emotional and behavioral aptness
10.1021/jf802279h [DOI] [PubMed] [Google Scholar] Joseph J
In plain words, it may move the balance toward make more, break less, depending on the setting and the dose
Specifically, the relatively small sample size, the unbalanced male/female ratio (with a higher number of males in two of the three cohorts), and the short intervention period constrained our ability to assess the long-term effects of the Sucrosomial B12 formulation