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This is noteworthy as (1) many biologically active peptides contain an -helix (a large fraction of PPIs involve an -helix) and (2) those helix portions could potentially be replaced or partially replaced by oligoureas with minimal effect on the binding while improving the proteolytic resistance of the peptide

For first-fill success (a critical marker of initial access), industry reports suggest first-fill approval rates for Wegovy are only ~3035% on first try ( [3] ) ( [4] )

That doesn't mean there can't be a lawsuit

doi: 10.1111/jfbc.14287 66

Peak detection, deconvolution, alignment, and feature integration were conducted using MS-DIAL version 5.1