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It directly stimulates pro-opiomelanocortin/cocaine-and-amphetamine-regulated transcript (POMC/CART) neurons and indirectly inhibits neuropeptide-Y/agouti-related protein (NPY/AgRP) neurons through GABA neurotransmission, reducing appetite and promoting weight loss [40]
These options help cash-paying patients, say, in the deductible phase of their insurance, or those who are not insured (either no health insurance at all, or not insured for obesity medicines)
doi:10.1210/jcem.82.5.3943 Khorram O, Yeung M, Vu L, Yen SS
J., Lopez-Armada, M
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