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Another fatal liver injury, the Indian childhood cirrhosis (ICC), was also found to be associated with heavy deposits of copper, though in all other respects it was different from WD [204]

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For instance, psychological stress activates the hypothalamicpituitaryadrenal (HPA) axis and sympathetic nerves, leading to cortisol and catecholamine release that increases intestinal permeability and disrupts the gut habitat [14, 15]

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