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Going forward and back: The complex evolutionary history of the GPx

In adults, the liver was identified as the target of APAP toxicity in the 1960s [6-8]

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Important safety considerations include a boxed warning regarding thyroid C-cell tumors observed in rodents (though the relevance to humans is unknown) and contraindications for patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)