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Essential mitigation strategies include fasting morning blood draws, 24-h urine collections to integrate metabolite production over diurnal cycles, dietary adjustment in statistical models, and repeated measurements to capture intra-individual variability

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If side effects become significant at a given dose, staying at that level for an additional 4 weeks before attempting another increase is standard practice

doi:10.1016/j.cmet.2019.07.013 337

Best before the date indicated on the bottle