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The Evolving Understanding of Opioid Use Disorder Opioid use disorder has emerged as one of the most pressing and complex public health crises of the twenty-first century

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As with other agents that cause significant weight loss or gastrointestinal fluid losses, there are theoretical class-related risks that warrant attention, including gallbladder disease (cholelithiasis and cholecystitis have been reported with GLP-1 receptor agonists), and dehydration or acute kidney injury in the context of persistent vomiting or diarrhoea

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