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Beyond NSA-involving metals in the LC flow path, we also believe that ionic interactions between positively charged sites on peptides or related impurities and residual siloxide groups on commonly used silica particles can exacerbate NSA, leading to sensitivity issues and poor peak shapes

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J Pathol 236(3):278289 Weinberg F, Hamanaka R, Wheaton WW et al (2010) Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

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