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ADA selectively activates retinoic acid receptors (RAR-/), thereby inhibiting excessive proliferation and differentiation of keratinocytes, reducing follicular hyperkeratinization, and downregulating inflammatory cytokines such as IL-6, ultimately contributing to its therapeutic effects in acne (Waugh et al., 2004)
Recent research on metabolic reprogramming in MDSCs has revealed that they utilize fatty acid oxidation (FAO) as their primary energy source, characterized by increased mitochondrial mass and fatty acid uptake (181)
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Vitamin C helps to protect the skin from damage, while hyaluronic acid helps to keep the skin hydrated
(2021) 29:e3446
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