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The effect is most noticeable as more even skin tone rather than dramatic lightening, and it works best in patients with hyperpigmentation, melasma, or uneven pigmentation rather than as a generalized skin-lightening agent

Agati G, Brunetti C, Di Ferdinando M et al (2013) Functional roles of flavonoids in photoprotection: new evidence, lessons from the past

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Abstract Glutathione S -transferase Pi (GSTP) was originally identified as one of cytosolic phase II detoxification enzymes and also was considered to function via its non-catalytic, ligand-binding activity

Kakar S, Singh R, Semwal A