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This methodological heterogeneity, compounded by variations in DNA extraction protocols, sequencing platforms, and bioinformatic pipelines (including reference databases), contributes to the inconsistent reports of key fungal signatures in CLDs

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This study has some limitations including that the number of individuals for whom cardiometabolic measures were available in the AEMR and LAAD databases was quite low, with the exception of BP, which prevented us from evaluating the other cardiometabolic outcomes for the BMI and HbA1c subgroups

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