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Research has documented MT-IIs potent, dose-dependent pro-erectile effects in rodent, rabbit, and non-human primate models , with studies characterising ex copula erection frequency, latency to erection, and duration of response following MT-II administration at doses producing reliable and reproducible pro-erectile responses

Diet also influences the gut microbiome, which modulates systemic oxidative stress

The localization of this receptor is highly specific

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