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For instance, secondary A829P KIT mutation renders melanoma cells resistant to imatinib but has no influence on nilotinib and dasatinib, while the T670I KIT mutation exhibits resistance to imatinib, nilotinib as well as dasatinib, but can still be suppressed by sunitinib (154)

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Instead, they tailor dose adjustments based on each patients unique response to the treatment

Induction of alpha-synuclein aggregation by intracellular nitrative insult