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In this case, the effects were evident in reducing the stroke area, neuronal loss, and resulting microglial activation

The import of methionine is a vital step in one carbon metabolism, since methionine is an essential amino acid (AA), which is sequentially converted into S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), releasing methyl groups (CH 3 ) that will be used in DNA, RNA, and histones methylation (Figure 1B)