Heliyon Citrus polymethoxyflavones degrade estrogen receptor-alpha (ER) and combine with tamoxifen for the treatment of estrogen receptor-positive breast cancer
5 Obesity portfolio goes beyond GLP-1 AstraZeneca is building optionality: AZD6234 (long-acting amylin) Phase 2 readout H1 2026 AZD6234 + AZD9550 (GLP-1/glucagon combo) Phase 2 readout H2 2026 $1.2B upfront to CSPC Pharmaceutical Group for ex-China rights to eight programs, led by SYH2082, a once-monthly GLP-1R/GIPR agonist My takeaway Withholding data is risky but moving into Phase 3 is louder than any slide
Its not dangerous, but it wastes peptide on systemic distribution that contributes nothing to cosmetic endpoints
It catalyzes the reduction of glutathione from the oxidized form of GS-SG, and all other enzymes of the glutathione system use it: 2 NADP + GS-SG 2 NADP + 2 GSH The reduction of oxidized glutathione is carried out with the participation of NADP + reduction systems on the pentose phosphate pathway of glucose-6-phosphate oxidation ("Embden-Meyerhoff shunt"): NADP + + G-6-P NADP + + + 6 phosphogluconate Glutathione transferase catalyzes the reaction: RX + GSH = HX + GS-SG Some forms of glutathione transferases, like glutathione peroxidases, are capable of reducing lipid hydroperoxides to hydroxy acids (LOH) [12]
Be alert, because rapid weight loss can contribute to gall bladder problems