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In contrast, the CysSSH levels in liver and lung tissues of CARS2-deficient heterozygous mice were reduced by more than 50% compared with those of WT mice, highlighting the principal role of CARS2 in CysSSH biogenesis (Zainol et al., 2023)
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In neonates, inherited defects of any of the enzymes of the urea cycle lead to hyperammonemia , which impairs the function of the brain, causing encephalopathy
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Fatty acid metabolism in the mitrochondria, producing succinyl-CoA, which enters the Krebs (citric acid) cycle
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