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Firstly, antibiotic resistance, particularly to macrolides such as clarithromycin, has been increasing, leading to a higher treatment failure rate ( H

DPP-4 has two mechanisms of action: first as a membrane spanning protein, where it binds and activates adenosine deaminase complexing protein and transfers intracellular signals via dimerization

BMC Bioinformatics 25 , 67 (2024)

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Trimethylamine-N-oxide TMA, which forms TMAO in the liver, is generated by the action of the gut microbiota by using dietary precursors such as choline, choline-containing compounds, betaine, and L-carnitine (87)