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They act as biological response modifiers, activating or suppressing immunity in response to stimuli

Several viruses, including IAV and HIV-1, utilize mitochondrial apoptosis to facilitate viral spread, although some delay apoptosis early in infection to optimize replication ( 2.5 Viral-induced mtDNA release and cross-talk with innate immune signaling pathways Once released into the cytosol, mitochondrial DNA (mtDNA) functions as a potent DAMP that activates multiple innate immune pathways

10.4103/0366-6999.190667 482 WangJ.XiaoM.WangJ.WangS.ZhangJ.GuoY.et al (2021)

Insert the needle using a smooth, dart-like motion until it reaches the muscle