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If the weight is coming off too quickly, you may need to downregulate a dose or perhaps switch to a medicine thats less potent. Siegel points out that the lower 4 mg retatrutide dose yielded a 19 percent body weight reduction, with a significantly lower rate of discontinuation, suggesting this may be a more tolerable option for many

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Researchers then began to investigate these effects in adults with obesity and co-existing Type 2 diabetes