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Animals fed on a selenium deficient diet exhibit a significant reduction of testicular GPx activity and an accompanying loss of germ cells from the germinal epithelium of the testes.16 Moreover, selenium administration prior to the creation of oxidative stress in the testes using the torsion/detorsion model (see later) to create ischemia-reperfusion injury, has been found to suppress lipid peroxidation and improve the histopathological profile.17 Small Molecular Mass Antioxidants In addition to the major ROS processing enzymes, the testes rely heavily on small molecular weight antioxidant factors for protection against oxidative damage

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However, there is considerable research showing that the bioavailability of peptides and proteins that are taken directly into the gastrointestinal tract is very poor

As peptide research expanded, attention shifted toward understanding how peptides behave within carrier systems and structured formulations