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Clinical Evidence: Why GLP-1 Works for Weight Loss and Diabetes The landmark SUSTAIN and SELECT trials demonstrated that GLP-1 agonists reduce body weight by 5 to 22 percent depending on the medication, dose, and baseline characteristics

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For example, while the SUSTAIN-6 study included patients with proliferative DR (PDR) and diabetic macular edema (DME), other CVOTs, such as PIONEER 6, did not

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