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Incretin hormones regulate glucose-dependent insulin secretion in RIN 1046-38 cells: mechanisms of action

Humoral factors from adipose tissue or adiposity signals, leptin and insulin, are mostly involved in the long-term regulation of food intake and energy metabolism as dictated by energy needs and the amount of energy stores, and can act on both cell types simultaneously to produce satiety through appetite suppression or hunger when the body is in a negative energy state (hungry) [14,15]

Because folate status is a major determinant of blood homocysteine concentrations, the possible contribution of elevated homocysteine to the pathogenesis of NTDs has been postulated

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