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Third, the APR-017 and LCS3 induced increase in ROS, decrease in GSH, and inhibition of cell growth in VRK2-KO cells could be reversed by supplying a GSH compensator

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But they come with significant drawbacks: high cost, injection site reactions, increased infection risk due to immune suppression, and the development of anti-drug antibodies over time that can reduce efficacy

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This includes the elderly and those with neurological issues