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Their baseline butyrate production is often already lower than healthy controls, so even modest glutathione-induced microbiome shifts can push them into symptomatic constipation
Mycologia 92(6):10331042 Tan SX, Greetham D, Raeth S, Grant CM, Dawes IW, Perrone GG (2010) The thioredoxin-thioredoxin reductase system can function in vivo as an alternative system to reduce oxidized glutathione in Saccharomyces cerevisiae
Tirzepatide (Mounjaro) has also been shown to significantly reduce the severity of sleep apnoea, mostly because weight loss puts less pressure on the airways