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Under the therapeutic concentrations, approximately 60%90% of APAP is metabolized in the liver by glucuronidation and sulfation, with a small part (approximately 5%15%) being metabolized by the cytochrome P450 pathway (CYP450) ( via two pathways to form the toxic intermediate N-acetyl-p-benzoquinone imine (NAPQI) and the non-toxic catechol metabolite 3-hydroxy-APAP (3-OH-APAP) (Figure 1)

This article is for educational purposes and discusses research findings from laboratory studies

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The economic rationale is airtight because 88.5% of obesity's cost increase falls on third-party payers, which is a textbook negative externality justifying public intervention

In contrast, while HCG is cheaper initially, it might require more cycles or supplementary treatments over time to achieve similar weight loss outcomes