12 CuiJ.CuiC.CuiY.LiR.ShengH.JiangX.et al (2017)
Vivarelli S, Salemi R, Candido S, Falzone L, Santagati M, Stefani S, Torino F, Banna GL, Tonini G, Libra M
Further Improved and Durable Response For patients with very high BMI, there is a critical need for new MoAs that provide improved efficacy approaching or surpassing the benchmarks set by bariatric surgery (2530% weight loss), either as a single agent or as a combination approach
When comparing DA4-JC and DA5-CH with liraglutide or dual agonists that do not contain the cell-penetrating motifs, we found that our dual agonists were superior, and there was a clear correlation between the ability to cross the BBB and to protect the brain from toxins (Zhang et al., 2020)
This is partially in line with a previous study from our group where GSH levels in an overlapping dorsomedial prefrontal region were not correlated with ADOS scores in adults with ASD