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Binge ethanol effects on prefrontal cortex neurons, spatial working memory and task-induced neuronal activation in male and female rats

Dabrafenib plus trametinib versus dabrafenib monotherapy in patients with metastatic BRAF V600E/K-mutant melanoma: long-term survival and safety analysis of a phase 3 study

Human studies have shown dose-limiting toxicities with NAMPT inhibitors, including gastrointestinal, hematologic, and metabolic effects. Animal studies also demonstrate harm to normal tissues when NAD+ production is reduced. These findings highlight a key challenge: targeting NAD+ metabolism in cancer is difficult because lowering NAD+ can harm healthy cells as much asor more thancancer cells

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