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Data availability The datasets generated and analyzed during this study are included in the Supplementary files

Molecular Specifications CAS Number 221231-10-3 Molecular Formula CHNOS Molecular Weight 1817.08 g/mol Physical Form Lyophilized powder Storage 20C long-term

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Non-hospital costs : These include physician services costs obtained from the Ontario Schedule of Physician Benefits, laboratory fees from the Ontario Schedule of Laboratory Fees, drug costs from the Ontario Drug Benefit Formulary, and device costs from the perspective of local health care institutions whenever possible, or from the device manufacturer

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