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Introduction The biological effects of the Glucagon-like peptide-1 (GLP-1) are mediated by binding to its receptor, GLP-1R, a specific seven-transmembrane receptor guanine nucleotide-binding protein (G-protein) coupled receptor (GPCR) ( The direct interaction between GLP-1R and Cav-1 regulates the proper targeting of the GLP-1R to the plasma membrane, the receptor trafficking, and the activation of the intracellular signaling pathway

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