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Moreover, iron is a critical cofactor for core bioenergetic processes such as mitochondrial respiration and oxygen transport and the Fe2+ required for ferroptosis (32)

In laboratory research, GHK-Cu is used as a biochemical tool to study copper-dependent signaling pathways, extracellular matrix (ECM) regulation, redox balance, and transcriptional modulation in controlled in vitro and preclinical experimental models

10.1007/s00213-009-1605-5 34 EpelbaumJ.GuillouJ

Here, a luminescent-based assay was applied to CuCl-treated HepG2 and HepG2 ATP7B-KO cells, in which RLU are proportional to HO levels (Fig