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There are concerns that these medications, or their compounded variations, may be associated with severe gastroparesis, also known as stomach paralysis

PLoS ONE 12 , e0168234 (2017)

They include Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), DRESS syndrome, and anaphylaxis [27]

Although several studies have stated that leptin can be an effective pharmaceutical tool for treating obesity in leptin-deficient states, the administration of exogenous leptin does not significantly decrease adiposity in the majority of instances of human obesity