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Both peptides possess antimicrobial activities against Gram-negative and Gram-positive bacteria, eNAP-2 acts additionally as an inhibitor of microbial proteases [34]

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An in-depth investigation suggested that IGF-1 stimulates human articular chondrocytes to synthesize proteoglycans by activating the PI3K/Akt/mTOR signaling pathway without activating the Ras/Raf/MEK/ERK pathway [18]