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This reduces the thermal shock to the tissue on delivery and can meaningfully reduce the stinging sensation

10.1146/annurev.immunol.25.022106.141623 58 JoshiM.KimJ.D'AlessandroA.MonkE.BruceK.ElajailiH.et al (2020)

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Other patients have been forced to ration or halt doses because the drugs are costly $1,000 to $1,300 per month and insurance coverage varies or because demand has far outstripped supply, Rothberg noted