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Description

it acts as a tumor suppressor in the initial stages but facilitates tumor progression in later stages (Miller and Thorburn, 2021)

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A successful example of ADCs using a non-cleavable linker is the humanized anti-HER2 antibody-maytansine conjugate trastuzumab emtansine (T-DM1, or Kadcyla ) (LoRusso et al., 2011

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4A) and in the IML (Fig

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